Intercellular Junctions Important in Sealing the Space
New insights into functions regulation and pathological roles of tight junctions in. They consist of a network of claudins and other proteins. 11w1xswii8uf1m These junctions are assembled by a network of integral transmembrane proteins claudins occludin junctional. . Intercellular junctions in endothelial cells. Tight junctions perform two vital functions. Tight junctions are present in tight and leaky epithelia. The extracellular domains of these proteins join directly to one another to occlude the intercellular space Figure 19-5. Extracellular matrix and intercellular junctions. These spaces are important in assisting the transfer of small molecules across capillary walls. The foremost apical layer of the epithelium contains tight junctions that appear as a series of focal connections between adjacent cells and serve as a barrier to the diffusion of molecules through the paracellular pathway by sealing t...